These are my other thoughts and intrests. They might not have to do with surviving life but they are things that intrest me enough to put research time into.

Traveling with Phones

Traveling out of the country

How do carrier proteins transport ADP and ATP in and out of mitochondria? by MRC Mitochondrial Biology Unit

How do carrier proteins transport ADP and ATP in and out of mitochondria? The mitochondrial ADP/ATP carrier protein in the mitochondrial inner membrane, which carries out the vital task of transporting ADP into mitochondria and ATP out. Credit: MRC Mitochondrial Biology Unit Scientists at the MRC-MBU in Cambridge, U.K., have discovered how a key transport protein, called the mitochondrial ADP/ATP carrier, transports adenosine triphosphate (ATP), the chemical fuel of the cell. This process is vital to keep us alive, every second of our lives, for all of our lives. This work will help us understand how mutations can affect the function of these proteins, resulting in a range of neuromuscular, metabolic and developmental diseases. Cellular structures, called mitochondria, are the powerhouses of our cells. Every day, we humans need our own body weight in ATP to fuel all of the cellular activities. Nerve impulses, muscle contraction, DNA replication and protein synthesis are just some examples of essential processes that depend upon a supply of ATP. Since we only have a small amount of ATP in our body, we need to remake it from the spent product ADP (adenosine diphosphate) and phosphate using an enzyme complex, called ATP synthase, which is located in mitochondria. In this way, every molecule of ATP is recycled roughly 1300 times a day. For ADP to reach the enzyme, and for the product ATP to refuel the cell, each molecule has to cross an impermeable lipid membrane that surrounds the mitochondria. The mitochondrial ADP/ATP carrier is involved in the transport of ADP in and ATP out of mitochondria. The carrier cycles between two states; in one state, the central binding site is accessible for binding of ADP, called the cytoplasmic-open state, and in another, the binding site is accessible for binding newly synthesized ATP, called the matrix-open state. A key question has been how the protein is able to convert between these two states, changing its shape to transport ADP and ATP specifically, without letting other small molecules or ions leak across the membrane. The paper, "The molecular mechanism of transport by the mitochondrial ADP/ATP carrier," published in Cell, describes how scientists have solved the structure of the carrier trapped in the matrix-open state. The carrier was trapped in this state by using a compound called bongkrekic acid, a lethal toxin that binds to the protein and stops it from working. The researchers could also rely on Nanobody technology. Nanobodies are fragments of llama antibodies, which bind specifically to the matrix-open state, and the structure of carrier-nanobody complex with bound bongkrekic acid was determined by X-ray crystallography. Together with earlier structures of the cytoplasmic-open state, this discovery reveals how the carrier works at the atomic scale. The carrier is incredibly dynamic, using six moving elements to transport ADP or ATP across the membrane in a unique and carefully orchestrated way. The ADP/ATP carrier is just one member of a large family of related transport proteins that bring different compounds in and out of mitochondria, and based on this discovery, the scientists believe that this mechanism is likely to work in a similar way for the whole family. There are many diseases associated with dysfunction of these carriers and for the first time we understand how mutations affect their molecular function.

when did we become human

Buffy the Vampire slayer

by episode 2 Buffy had aquired what no other slayer before her had, friends. And these friends would change the cycle of slayers forever.
And I found this on one site ———- One of the most memorable episodes of Buffy the Vampire Slayer is "Restless," which mainly consists of dream sequences. In one of these, two characters, Tara and Willow, talk while Willow paints Greek letters on Tara's naked back. The inscription must have been done hastily, because the initial letter in the eleventh line is actually calligraphed as a Latin "S" instead of a Greek "Sigma." For a long time, I wondered what the text was and doubted that it could be identified or reproduced. Happily, I learned that it is the poem "Immortal Aphrodite" by Sappho. While I am unable to present the text in actual Greek letters, I do offer below a transciption using Latin letters to represent the Greek text. While other websites (listed at the bottom of this page) can tell you more about this poem, no one else seems to have bothered to show how the calligraphy appears on Tara's back on television. I have done so here, complete with split words that begin at the end of one line and continue on the next. (Note that the only way of knowing how most lines end is to know how the next line begins, because the camera angle used in the television film shows us the left side of Tara's back far more clearly than the right.) While the words on Tara's back run together, I have put spaces between each word for the purpose of clarity, and I put a period at the end of the short line that ends the first stanza. I also finish the second stanza even though, in the television film, it is impossible to see whether the last line of the stanza has been completed or not. (If it is, the poem must continue on Tara's butt, which is not shown.)
POIKILO' THRON' ATHANA/ T' APHRODITA PAI DI/ OS DOLOPLOKA, L/ ISSOMAI SE ME M'/ ASAISI MED' ONIAI/ SI DAMNA POTNI/ A THUMON. ALLA TUID' ELTH' AI/ POTA KATEROTA T/ AS EMAS AUDO/ S AIOISA PELOI/ EKLUES, PATROS DE DOMON LIPOISA CHRUSION ELTHES And here is Diane Rayor's translation of the above portion of the poem: On the throne of many hues, Immortal Aphrodite, child of Zeus, weaving wiles--I beg you not to subdue my spirit, Queen, with pain or sorrow but [ALLA] come--if ever before having heard my voice from far away you listened, and leaving your father's golden home you came... It is worth noting that Sappho was not a dry poet in the modern sense, but a song writer. Unfortunately, the music that went with these lyrics has been lost. So, too, have most of her lyrics been lost.
Back to the index Links to other sites on the Web A good intro to IMMORTAL APHRODITE A site devoted to Tara featuring this poem Another site that explains this poem's use by Tara and Willow Hosted by www.Geocities.ws

DDO Dungens and Dragons Online MMO

Here is a statement from the developer from DDO forums
I realized I ought to put a post on the new forums so that people can still find this. I built the DDO Gear Planner website a while ago to help solve your gear tetris problems. You tell it which affixes you care about, and it will suggest gear that has those things. It's also super helpful for figuring out what bonus types you're missing for a particular affix. The website lives at https://ddo-gear-planner.netlify.app/ and is mobile friendly! You can easily share your builds by copying-and-pasting the admittedly-long URL. For example, here's my Ice Druid. If you scroll down, you can see that I have 30 out of 34 available points for Wisdom, and am missing the Exceptional bonus entirely. Clicking on any of the bonus type boxes shows you a list of gear with that bonus on it. I don't spend much time on it these days, but most of the data is pulled nightly from the wiki, so new gear shows up automatically. I occasionally push updates when inspired, so feel free to leave suggestions... or better yet, make your own contributions through the GitHub repo, https://github.com/illusionistpm/ddo-gear-planner

Canith Crafting

A student seeing someone shot vs
A student being hit by a car